Salmon DNA skin boosters, also known as polynucleotide (PN) injectables, are widely used in aesthetic medicine for their regenerative potential. Unlike conventional skin boosters that focus mainly on hydration, polynucleotide treatments work deep within the skin to support repair, regeneration, and long-term improvement of skin quality.
In Singapore, these treatments have become increasingly sought after by both men and women who wish to improve skin texture, hydration, and resilience in a natural and scientifically backed way. At Mizu Aesthetic Clinic, our medical director Dr YZ Tan has been using polynucleotide skin boosters for many years and is also an appointed trainer for this treatment.
Polynucleotides are biopolymers — naturally occurring chains of nucleotides that form the fundamental building blocks of DNA and RNA. In the context of skin rejuvenation, polynucleotides used in skin boosters are typically derived from purified salmon DNA, chosen because of its strong biocompatibility with human skin.
Polynucleotides are a purer and more concentrated form of Polydeoxyribonucleotides (PDRN).
When introduced into the dermis:
These combined effects explain why salmon DNA boosters are often described as regenerative rather than purely hydrating, offering a different mechanism of action compared to hyaluronic acid-based boosters.
Because they work on the cellular and structural level, polynucleotide skin boosters are often recommended for patients looking to:
Compared to hyaluronic acid skin boosters, which excel in providing hydration and glow, polynucleotides deliver longer-term repair and rejuvenation by addressing the root causes of skin deterioration.
A topical numbing cream is applied to ensure comfort. The solution is then injected into the dermis using fine, precise techniques. At Mizu, Dr Tan uses the manual injection technique to minimise product leakage, achieve even distribution and reduce downtime. LED light therapy may be added afterwards to support healing and results.
Most patients benefit from 3 to 4 sessions, spaced 3 to 4 weeks apart. Maintenance is usually recommended once every 6 to 12 months.
Some patients may notice improvements such as smoother and more hydrated skin within days, while collagen remodelling and textural improvements become more apparent after a course of treatments.
Mild redness or small bumps may appear immediately after injection, but these typically subside within 1 to 2 days. Patients can usually resume normal activities the same day.
Salmon DNA skin boosters are suitable for both men and women, usually from their mid-twenties onwards. They may be considered for those concerned about early signs of ageing, dullness, dehydration, or acne scarring.
Dr YZ Tan is an appointed trainer for polynucleotide treatments, guiding other doctors in the technique and application of this therapy. With years of practical experience and deep understanding of regenerative injectables, Dr Tan has refined protocols that balance comfort and safety with optimal outcomes.
In addition to injectable treatments, topical skincare containing polynucleotides has also been developed to support daily skin health. One such ingredient is c-PDRN® (Cosmetic Polydeoxyribonucleotide), a derivative of salmon DNA fragments similar to those used in regenerative injectables, but formulated for topical use.
c-PDRN® is designed to help improve hydration, support skin repair, and maintain a healthier skin barrier as part of a regular skincare routine. While topical products do not replace in-clinic procedures, they can complement professional treatments by providing ongoing care at home.
A selection of Rejuran skincare products containing c-PDRN® is available through our shop page, offering patients convenient access to formulations that extend the benefits of polynucleotide technology into their daily regimen.
Take the first step towards clearer, healthier-looking skin. Schedule a personalised consultation with our medical team to discuss your acne concerns and explore the best treatment options for your skin.
This page is intended for educational purposes and does not constitute medical advice. For an accurate diagnosis and personalised treatment plan, please consult with our licensed medical professionals.
