As we age, collagen – the key structural protein that keeps our skin firm and youthful – begins to decline. This leads to visible signs of ageing such as fine lines, sagging, and loss of volume. For individuals seeking natural-looking results without surgery, collagen biostimulators have become an increasingly popular choice. Unlike traditional fillers that provide instant volume, these treatments work by stimulating the skin’s own collagen production for gradual, natural-looking and long-lasting rejuvenation.
An ingredient that is commonly used in collagen biostimulator treatments is Poly-L-lactic acid (PLLA). This is one of the most established biostimulator ingredients and has been used in aesthetic medicine for many years. It targets fine lines, wrinkles, sagging, and other signs of ageing caused by collagen loss, gradually helping restore skin structure and volume. Sculptra is a bio-stimulator that helps stimulate your natural collagen production to smooth facial wrinkles, improve volume loss, and enhance skin tightness.
The PLLA particles stimulate the natural growth of new collagen by activating fibroblasts in the skin. Fibroblasts are cells responsible for producing connective tissue such as collagen and elastin, resulting in fuller and tighter skin. Over the course of several months, this process improves skin density, restores facial volume, smooths wrinkles and enhances elasticity.
Collagen biostimulator treatments using PLLA may last up to two years. During this period, the PLLA particles continually stimulate collagen and elastin production through the skin’s regenerative abilities. After this period, it breaks down into water and carbon dioxide and is completely eliminated from the body.
PLLA is often used to address concerns such as:
Skin laxity and fine lines
Loss of volume in the cheeks and temples
Deep nasolabial folds and marionette lines
Collagen biostimulators provide a gradual, natural-looking enhancement. Key benefits include:
Lifting effect
Firmer, more elastic skin
Reduction of post-acne scars
Replenishment of lost tissue volume
Improvement in fine lines and wrinkles
Restoration of skin structure and support
Long-lasting results as collagen continues to build over several months
A refreshed and rejuvenated appearance without the need for surgery
PLLA collagen biostimulator is used to improve shallow-to-deep wrinkles and folds on the face. The treatment areas include the regions around:
Marionette lines
Nasolabial folds
Cheeks
Temples
The under-eye/tear trough and the forehead are not indicated for treatment due to the thinness and different skin structure of these areas.
Although collagen biostimulators may be administered similarly to some fillers, they do not directly volumise hollow areas as fillers do. The results are not immediate because collagen is stimulated over time, tightening skin and improving volume loss. In contrast, fillers provide immediate effects but do not stimulate collagen and are mainly used to enhance areas with volume loss without improving texture and laxity.
The treatment is performed using a cannula after applying numbing cream. A cannula is a blunt needle that does not damage blood vessels, resulting in minimal side effects and bruising. Using a cannula allows for even distribution of the treatment solution around the face, ensuring the PLLA microparticles are evenly distributed under the skin for optimal results. Your doctor must be experienced and familiar with the specific technique required for collagen biostimulator administration.
Most clinical study participants saw results as soon as 1 to 2 months. These results will continue to build as new collagen takes up to 6 months to form.
Depending on the initial condition of the skin and the desired result, 1 to 3 sessions spaced a few months apart are recommended.
Results typically last 12 to 24 months depending on the initial condition of the skin and maintenance post-treatment.
Most patients experience minimal downtime. Mild puffiness or soreness at injection sites may occur but usually resolves within a few days. There may be a slight chance of bruising, although this risk is reduced when a cannula technique is used.
In rare cases, small nodules may form if the product is not evenly distributed. This can happen due to uneven collagen and volume production when done incorrectly, or when too much is injected in one area. Choosing an experienced injector is important for minimising such risks.
At Mizu Aesthetic Clinic, collagen biostimulators have been part of our anti-ageing treatment portfolio for many years. Dr YZ Tan, our medical director, is not only experienced in administering these treatments but also serves as a trainer in the use of poly-L-lactic acid for other doctors. His experience ensures that patients receive treatment safely and effectively, tailored to their individual facial anatomy and concerns.
Take the first step towards clearer, healthier-looking skin. Schedule a personalised consultation with our medical team to discuss your acne concerns and explore the best treatment options for your skin.
This page is intended for educational purposes and does not constitute medical advice. For an accurate diagnosis and personalised treatment plan, please consult with our licensed medical professionals.
