Skin Boosters for Rejuvenation

What is it?

Skin boosters for rejuvenation and repair, such as the Rejuran Healer and Plinest, are made up of polynucleotides (PN). Polynucleotide chains are DNA fragments that repair damaged dermal (skin) cells and assist in collagen stimulation. Rejuran is also known in the market as 婴儿针 (in Mandarin).

What are Polyneucleotides (PN)?

Polydeoxyribonuclotides (PDRN) has previously been used as a skin injectable for anti-ageing and hair growth treatments in Korea, and medically for skin regeneration purposes. PN is a purer and more concentrated form of PDRN and has stronger regenerative properties.

PN is a biopolymer consisting of nucleotide monomers bonded together, forming the building blocks of DNA and RNA. When used in skincare, PN serves as a regenerative ingredient that can work wonders for the skin. PN can be obtained from different sources and are renowned for their ability to promote collagen production, repair damaged skin cells, improve skin hydration and elasticity, and restore the skin’s natural barrier.

PN in Rejuran is extracted from Salmon DNA, while Plinest is extracted from Trout DNA, which are known to have excellent biocompatibility with human skin without any immune response, thus making this skin rejuvenation treatment highly suitable for most people.

Doctor Performing Skin Booster Treatment on Woman's Face for Acne Scar

What are the different types?

Rejuran comes in 3 forms.
  • 1
    Rejuran Healer for full face rejuvenation
  • 2
    Rejuran S for scar treatment
  • 3
    Rejuran I for under-eye rejuvenation

Plinest comes in 2 forms.

  • 1
    Plinest for full face rejuvenation
  • 2
    Plinest Fast for under-eye rejuvenation

What it does

  • Group 176
    Activates revitalisation of the skin by promoting cell growth through inducing fibroblast production. (Fibroblasts are responsible for collagen production.)
  • Group 176
    Slows down ageing and thickens the skin barrier for a stronger defense barrier against environment and non-environmental factors that cause premature aging of the skin.
  • Group 176
    Improves skin elasticity by increasing collagen production and promotes healing of damaged skin as well as reducing fine lines and wrinkles on the face, neck, and unde-eyes. Highly effective for skin and full face rejuvenation.
  • Group 176
    Improves skin hydration by up to 14.69% in a study done Korean dermatologists.
  • Group 176
    Helps reduce sunken acne scars and minimises pores by repairing damaged skin and collagen structures damaged by previous inflammation from acne.

What conditions can it used for?

  • Group 176
    Ageing and loose skin
  • Group 176
    Fine lines and wrinkles
  • Group 176
    Acne scars and large pores
  • Group 176
    Rough and dehydrated skin
  • Group 176
    Overall maintenance for healthier, brighter and younger skin

The ever-popular skin boosters or 水光针, is a hyaluronic acid injectable skin rejuvenation treatment.
Hyaluronic acid skin boosters are effective for hydration and brightening of the skin, but does not have collagen-stimulating and anti-ageing properties like Rejuran Healer or Plinest as these contain polynucleotides. 

Aside from hydration, one can expect tighter, brighter, and softer skin from Rejuran Healer or Plinest treatments.
Skin boosters and Rejuran/Plinest can be done in combination for better results.

frequently asked questions

Before the procedure, topical numbing cream is applied so that the treatment is comfortable. 

Skin boosters are injected into the dermis layer of the skin either by an injector gun, or by manual injections with a very small needle. Dr YZ Tan recommends the manual injection technique as it ensures that none of the product leaks during the procedure for best results. Also, with manual injections, the downtime is lesser and minimal.

After the procedure, a LED light therapy will be used to further enhance results and recovery.

Both Rejuran Healer  and Plinest skin booster treatment utilise 1 syringe (2ml) for a full face treatment. 3 – 4 treatments are recommended, 3 – 4 weeks apart.
As maintenance, a single treatment is then repeated once every 6 – 12 months to fight against the effects of ageing.

The restoration/skin rejuvenation process is largely dependent on individual’s cellular turnover rate, but a marked improvement to the skin can usually be observed within a few days of the first treatment, and the best results are observed after 3-4 treatments.


Downtime is very minimal as the needle used is very small. Patients may experience slight bumpiness of the skin right after the treatment, but this usually subsides within 30 – 60 mins.

Minimal redness is experienced with manual injections, which is why it is also a popular choice with Dr Tan!

We start ageing and losing collagen from our mid-twenties, hence it may be recommended for both men and women from their mid-twenties onwards. It is also suitable for people suffering from sunken acne scars and poor skin texture.

More about skin boosters as an acne scar treatment

Find out more about how Rejuran S is used for acne scarring!

Cursor Image