Polynucleotide Skin Booster Treatment: An In-depth Guide


Ageing is an inevitable part of life, bringing with it wisdom and confidence. However, it also comes with less welcome signs like fine lines, wrinkles, and sagging skin. While conventional skincare products containing retinol, vitamin C, and hyaluronic acid offer some benefits, their effects may be limited.

Enter polynucleotide skin boosters, a treatment designed to address common signs of ageing from within. This article explores what polynucleotide is, its benefits, and how treatments like Rejuran and Plinest can enhance your skincare routine.

What are polynucleotides?

Polynucleotide is a chain of nucleotide monomers, which are fundamental building blocks of DNA and RNA. It is derived from sources like salmon DNA in Rejuran and trout DNA in Plinest.

These molecules penetrate deep into the skin layers, promoting repair and rejuvenation at a cellular level. Unlike surface-level skincare products, polynucleotides work from within to strengthen the skin and boost the efficacy of other anti-ageing products you use.

Benefits of Polynucleotide Skin Boosters for Ageing Skin

Polynucleotide benefits

Polynucleotide skin boosters offer multiple benefits, making them a good choice as an anti-ageing treatment:

  • Stimulates Skin Cell Regeneration

Polynucleotides enhance cellular metabolism and increase the synthesis of DNA and RNA. This repair and regeneration of skin cells leads to healthier, more vibrant skin cells, strengthening the skin barrier for a stronger defence against environmental and non-environmental factors that cause premature skin ageing.

  • Promotes Collagen Remodelling

Polynucleotides trigger the body’s natural production of collagen and elastin, thus improving skin elasticity and reducing fine lines on the face, neck, and under-eyes. It also reduces sunken acne scars and minimises pores by repairing collagen structures damaged by previous acne inflammation.

  • Enhances Skin Hydration

Polynucleotides boost hydration by increasing the skin’s ability to retain moisture, which diminishes with age. This helps to give the skin a plumper and smoother appearance.

Treatment Areas for Polynucleotide Skin Boosters

treatment using Polynucleotide

Polynucleotide skin boosters can be injected into various areas:

  • Full face: Targets common ageing signs such as fine lines, wrinkles, loose skin and enlarged pores.
  • Under-eye: Reduces fine lines and revitalises the delicate skin under the eyes.
  • Neck: Often a neglected area, polynucleotide skin boosters can improve the skin’s elasticity on the neck and reduce the appearance of lines and loose skin. 
  • Acne scars: Specific polynucleotide skin boosters such as the Rejuran I can be injected into sunken acne scars to trigger collagen remodelling and improve its appearance.

What to Expect During the Treatment

1. Skin cleansing

Your skin will be thoroughly cleansed to remove any impurities. This is especially important as the treatment involves injections.

2. Numbing cream application

To minimise discomfort, a topical numbing cream will be applied. This is usually left on for about 30 minutes.

3. Skin booster treatment

Once your skin is thoroughly cleansed and numbed, your doctor will use a fine needle to administer the polynucleotide skin booster gently and carefully into your skin.

4. Post-treatment immediate aftercare

A soothing gel and yellow LED light will be left on for 10 minutes after the skin booster treatment to calm the skin and reduce redness.

What is the Downtime?

As with most treatments that consist of injections, there will be downtime of about 1-2 days. This includes:

  • Redness: Mild redness around injections sites, which should subside in a day.
  • Mild swelling: Temporary swelling right after the treatment that will gradually decrease over the day.
  • Tenderness: There may be slight tenderness around injection sites, which typically also resolves in 1-2 days.
  • Mild bruising: Bruising can occur with any treatment that involves injection. This is usually mild and will fade after a few days.


Post-treatment Care: The Do’s and Don’ts

Proper aftercare ensures optimal healing:


  • Maintain skin hygiene with a mild cleanser.
  • Apply sunscreen: Avoid sun exposure and apply sunscreen with SPF 50 PA+++.
  • Stay hydrated by drinking at least 1.5L of water daily.


  • Drink alcohol for at least 24 hours after the treatment. This will interfere with your skin’s healing process and may exacerbate bruising.
  • Use harsh exfoliant products like AHA/BHA or retinol for a week until your skin has healed. Your skin will be more sensitive after the treatment.
  • Exercise for at least 24 hours post-treatment. You may, however, continue your usual daily activities.

Final Thoughts

Polynucleotide skin boosters, such as treatments like Rejuran and Plinest, offer an effective solution for reducing fine lines, wrinkles, and sagging skin. By working from within, these treatments complement your existing skincare routine and provide long-lasting results.

At Mizu, we provide offer both Rejuran and Plinest skin boosters. Contact us for more details and to schedule a consultation.


How long do the effects of polynucleotide skin boosters last?

The results typically last between 6-9 months, depending on your lifestyle and skincare habits.

How many sessions are needed?

One session can address common ageing signs, but 3 sessions spaced 4 weeks apart is the recommended course of treatment for optimal results.

Are polynucleotide injections painful?

While there may be some discomfort, adequate numbing cream is applied to ensure the process is manageable.

Can I go to work after the treatment?

Yes, you can resume work immediately, ensuring you apply sufficient sunscreen to protect your skin.

Dr Tan Ying Zhou | Aesthetic Clinic Singapore

Dr Tan Ying Zhou, known as Dr YZ Tan, is the founder and Medical Director of Mizu Aesthetic Clinic.

His journey into aesthetics began with a medical degree from St. George’s, University of London, followed by an internship in Dermatology at the National Taiwan University Hospital.

Some of his favourite aesthetic procedures include nose augmentation and anti-ageing solutions, and he also serves as a trainer for emerging aesthetic doctors.

His philosophy revolves around personalised treatments tailored to each individual’s ageing concerns, aiming to transform the ageing process gracefully into a pleasant journey towards confidence and wellness.

Want to speak to a doctor about which skin booster treatment is for you? Drop us a message by clicking on the link below.

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