How do skinboosters work?

The original clinic-grade skinboosters were developed by Restylane, a Swedish-based manufacturer of dermal fillers. They were designed to ‘improve hydrobalance’ of our skin by providing long-lasting, intensified hydration from within the skin layer.

Most skinboosters in the market are made of hyaluronic acid, except for Rejuran (which we will touch on more), and helps provide hydration and improve subdermal collagen production.

Hyaluronic acid is capable of holding 1000 times its molecular weight in water, making it the gold standard ingredient for skin moisturizers and serums over skincare counters. Studies have shown that Hyaluronic acid not only helps improves skin hydration, it also aids collagen production, improve skin elasticity, provide anti-oxidative benefits, and reduces inflammation (that is why it is part of Dr. Tan’s preferred moisturizer for acne-prone skin!)..

Hyaluronic acid skinboosters are placed under the skin with precise injections with either an injector device or with individual manual injections after a round of topical numbing. These small deposits of skinboosters act like water reservoirs under the skin, absorbing and retaining moisture for long-term lasting hydration. This increase in hydration brightens the skin, resulting in plump, supple, and dewy skin.

Skinboosters also help increase collagen in our skin! The deposits of skinboosters increase fibroblast activity under the skin, and these fibroblast cells are responsible for collagen production. A Swedish study in 2014 reported that intradermal injection of Restylane Skinboosters resulted in increased collagen production and improved skin elasticity.

Types of skinboosters

So, what are some of the popular skinboosters available?
Let us touch on the most effective skinboosters available and approved in Singapore and how each stands out.


Restylane Vital/Vital light Skinboosters

The ‘original’ skinboosters, as these were the first skinboosters to be introduced to the market. Restylane skinboosters are partially cross-linked hyaluronic acid chains and contains up to 20mg/ml of hyaluronic acid per syringe.

Cross-linkages represents on how dense the hyaluronic acid chains are in the skinbooster. Imagine each chain having 1000 available space for water molecules to attach themselves to the hyaluronic acid. The more cross-linked the hyaluronic acid is, the less space there is for water molecules to attach themselves to. However, the more cross-linked the hyaluronic acid is, the longer the skinbooster effects last.


Teosyal Redensity I

Teosyal Redensity I, or RDI, is a Swiss-made skinbooster that is non-crossed link. Each syringe of RDI contains 15mg/ml of hyaluronic acid. The main selling point of Teosyal RDI is that it also contains 3 highly efficient and powerful antioxidants, 2 minerals, 1 vitamin and 8 amino acids. The notable antioxidants from this list is Glutathione. Glutathione is not only a powerful antioxidant, it is also the main ingredient in whitening drips (not allowed in Singapore). Therefore, Glutathione in Teosyal RDI helps makes the skin fairer while providing hydration from within. Read here on how Teoysal RD II helps with dark eye circles with Glutathione!


Juverderm Volite

Juvederm Volite is the new kid on the block in skinboosters. Juvederm Volite contains 13mg/ml of cross-linked hyaluronic acid per syringe. Although 2 syringes are required for the procedure, Juverderm Volite only requires 1 treatment compared to 3 treatments of other skinboosters, due to its unique cross-linkage and patented Vycross™ technology by Allergan (the makers of Botox and Juvederm fillers). 1 treatment of Juvederm Volite is sufficient to boost skin hydration and elasticity for up to 9 months. For those who does not fancy the downtime and injections, Juvederm Volite might just be the answer for you.


Rejuran Healer

Rejuran Healer

Rejuran Healer, one of the latest craze in aesthetic skinboosters, is not made of Hyaluronic acid – instead, it is made of PolyNucleotides (PNs), derived from salmon DNA ragments. Like Skinboosters, Rejuran is placed under the skin with precise injections and are usually placed slightly more superficially compared to most skinboosters.

Rejuran is essentially a ‘skin healer’, as its purpose is to repair cellular / DNA damange caused by both external (uv damage, pollution, etc) and internal factors (aging, scarring).

The polynucleotides in Rejuran Healer work by biologically stimulating the activity of fibroblasts in the skin. Fibroblast activity due to Rejuran is more intense compared to skinboosters as these DNA fragments directly trigger skin cells to repair themselves. Rejuran also works as a free radical scavenger – in other words, it reduces oxidative damage to our skin. Oxidative damage results from UV sun damage, pollution, stress, and ageing. Essentially, Rejuran’s results come from its ability to ‘turn back time’ and make our skin cells younger. The younger skin cells directly and indirectly improves skin hydration, skin tightening, brighter and younger looking skin, minimize pore size, and improve skin texture. Read here for more information about Rejuran Healer.

Where can skinboosters be injected?

where can you inject skinboosters on?

So which skinboosters are better for you?

Most patients at the clinic request for skinboosters that they already know about, and these are mostly due to online research or from friends who have done it before.

The type of skinboosters to choose will depend heavily on patients’ preferences, and also a thorough skin examination with our doctor(s).

Here is a breakdown of the different skinboosters and which should you consider:

Main Component
Treatments Needed
Unique Benefit
Suitable for

Restylane Skinboosters
20mg/ml partially cross-linked Hyaluronic acid
3 times, once a month. Last 12 months
Highest amount of Hyaluronic acid in any skinbooster. Long lasting.
Patients looking for more intense hydration for longer duration.

Teosyal Redensity 1
15mg/ml non cross-linked Hyaluronic acid + multiple vitamins and proteins
3 times, once a month. Last 9-12 months
Provides whitening and makes skin fairer. Provides vitamins and proteins for skin health. Slightly higher hydration effect due to non-cross linkages but shorter effects.
Patients looking for faster results, and fairer skin.

Juvederm Volite
13mg/ml cross-linked Hyaluronic acid
1 time. Last 6-9 months
Patented Vycross technology results in long lasting results with just 1 procedure.
Patients who prefer fewer treatments and downtime with long lasting results.

Rejuran Healer
Salmon DNA-derived Polynucleotides
3-4 times, once a month. Last 12-18 months
Anti-ageing benefits combined with improvement in skin health and texture.
Patients with skin with less elasticity or damaged skin (such as acne scars or open pores).


Dr. Tan personally recommends a combination of Rejuran with Hyaluronic acid skinboosters, as it yields amazing results. The combined effects usually result in brighter, firmer, more hydrated, younger skin with reduced fine lines and pore size. His preference is to combine Rejuran with either Restlyane or Teoysal skinboosters. As for stand-alone skinbooster treatments, Juvederm Volite is definitely one of the go-to treatments.

What is the preferred method of injection?

Skinboosters are either done by an injector device or by manual injections.

The procedure is more comfortable with the injector device but it is not suitable for Rejuran or cross-link hyaluronic acid skinboosters like Juvederm Volite as these skinboosters are more viscous and will sometimes block the injector device. The injector device also has a high chance of product leakage during injection and causes wastage.

Dr. Tan very much prefers the manual injection as it provides better effects, reduces wastage of the skinboosters and also reduces the amount of downtime from the procedure. Manual injections are slightly more uncomfortable, but still tolerable with numbing cream.

How fast do you see results from Skinboosters?

Results vary with individuals, but typically a non-cross linked skinboosters tend to show results after about 1-2 weeks. Rejuran, as it is more of a skin healer, takes a longer time to produce results due to the time cycle of cell rejuvenation and repair. Results typically shows after 2-3 weeks of the procedure.

How long is the downtime?

Downtime with manual injections, in the hands of a careful and experienced doctor, should only last for a maximum of 2 days with slight bumps (the skinboosters deposits). With an injector device, downtime tends to be 3 days or more as multiple needle punctures from the device are more forceful and can sometimes cause bruising easily.

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